Plan your trip to Puerto Rico and book a room at our Mayaguez Plaza Hotel, Best Western Signature, with a convenient location off Highway 2, in Downtown Mayaguez. Our Mayaguez location near University of Puerto Rico offers affordable accommodations with easy access to all of our community's major attractions, like unique restaurants, a vibrant night life, and picturesque beaches. We are just steps away from Plaza Colón, the main plaza in Mayaguez, where you can enjoy nearby restaurants and shops, and sightsee the historic statues and monuments.