Hotel Vitale, a luxury hotel on San Francisco's waterfront. This landmark San Francisco boutique hotel was designed to uniquely encompass modern luxury touches balanced with soothing natural elements. At this urban retreat, guests will experience a revitalizing stay, enhanced through Hotel Vitale's stunning water and city vistas, on-site Spa Vitale with outdoor roof-top soaking tubs, dramatic terraces and the Vitale's signature restaurant and bar.