The hotel is located in the modern part of Havana Miramar known as a residential area within walking distance of 5th Avenue. It is an elegant 5-star hotel with a mix of colonial and modern styles. It has several restaurants, such as "El Olivo" hospital food, The Restaurant "Don Quijote" Spanish food, The Snack Bar "Tops", the Café "Havana" and the Lobby Bar "Daiquiri". All rooms at the Fifth Avenue Hotel have air conditioning, telephone, minibar, safe, hairdryer, bathroom with tub and separate shower. Recreational amenities at the hotel include an outdoor pool, beauty salon, fitness center and sauna.

A continental breakfast buffet is served each morning, whilst à la carte and set menu options are available for lunch and dinner.